Cristina Cotobal

Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease

This study uses single-cell RNA sequencing to analyze immune cell transcriptional profiles in mucosal and circulatory compartments of Crohn's disease patients, revealing tissue-specific inflammation signatures and identifying circulating T cells with mucosal-like features.

Functional profiling of long intergenic non-coding RNAs in fission yeast

The paper functionally profiles long intergenic non-coding RNAs (lincRNAs) in fission yeast by analyzing mutant phenotypes across various conditions.

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements

The paper identifies age-related genome rearrangements in non-dividing fission yeast cells, linking them to R-loops and regulatory changes, and finds similar patterns in human brain cells.

Barcode Sequencing and a High-throughput Assay for Chronological Lifespan Uncover Ageing-associated Genes in Fission Yeast

This study introduces improved methods for studying chronological lifespan in fission yeast, identifying new ageing-associated genes with potential relevance to human ageing.

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

Pyphe: A python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

Pyphe automates and improves analysis of microbial fitness screens by processing colony size, viability, and growth curve data from low-cost imaging.

Long non-coding RNA repertoire and regulation by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeast

The paper identifies 5775 novel lncRNAs in fission yeast and characterizes their regulation by RNA-processing pathways.

Skip and bin: pervasive alternative splicing triggers degradation by nuclear RNA surveillance in fission yeast

This study identifies pervasive alternative splicing in fission yeast, showing that exon-skipping transcripts are mostly non-functional and degraded by nuclear RNA surveillance.