Annelien Verfaillie

This study uses single-cell and spatial multi-omics to analyze a malignant peripheral nerve sheath tumor, revealing chromosomal instability drives phenotypic diversity and spatial-temporal evolution.

Nova-ST is a cost-effective, high-resolution spatial transcriptomics platform that outperforms existing methods in sensitivity for mouse brain sections.

This paper introduces GRITIC, a method to time genomic gains in tumors, finding that copy number gains often accumulate after genome duplication.

The paper analyzes somatic substitutions in non-unique regions of the human genome across 2,658 cancers, revealing hidden mutations in coding sequences and regulatory elements.

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.