Jane Worthington

This study fine-maps RA and T1D loci outside the MHC, identifying causal variants and confirming their functional impact through allele-specific binding and enhancer activity.

The paper identifies a differentially variable DNA methylation signature in rheumatoid arthritis discordant monozygotic twins, suggesting epigenetic variability contributes to autoimmune disease.

The paper introduces BUHMBOX, a statistical method to distinguish pleiotropy from heterogeneity in genetic data, finding shared genetic bases in autoimmune diseases and between MDD and schizophrenia.

The paper identifies shared and distinct genetic risk variants across four autoimmune diseases using colocalization methods with shared control data, revealing novel associations and complex patterns.