Tom W. J. Huizinga

This study identifies symmetrical dimethylarginine (sDMA) as the central antigenic determinant recognized by anti-Smith autoantibodies in SLE, showing their high cross-reactivity to sDMA-containing viral epitopes.

The paper identifies a subgroup of SLE patients with high plasmablast frequency and IFN signature, enriched in those with Sm/RNP antibodies, linking IFN to B cell hyperactivity and autoantibody production.

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.

This paper develops G-Prob, a method converting genetic data into disease probabilities for inflammatory arthritis, improving diagnostic accuracy in rheumatology.

This study fine-maps RA and T1D loci outside the MHC, identifying causal variants and confirming their functional impact through allele-specific binding and enhancer activity.

The paper introduces BUHMBOX, a statistical method to distinguish pleiotropy from heterogeneity in genetic data, finding shared genetic bases in autoimmune diseases and between MDD and schizophrenia.