Developmental BiologybioRxivPreprint
Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mt-ISR
Virginie Petel Légaré, Christian J. Rampal, Mari J. Aaltonen…·Gary A.B. Armstrong
This study shows that loss of Chchd10 or Chchd2 in zebrafish causes ALS-like symptoms and Complex I deficiency, with double KO showing more severe effects and mt-ISR activation.
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