Anna H. Wu

The paper introduces pathway-based polygenic risk scores (pPRS) to detect gene-environment interactions, finding a significant interaction between NSAIDs and the TGF-β/GRHR pathway in colorectal cancer.

This study improves polygenic risk scores for colorectal cancer by combining Asian and European ancestry data, enhancing risk prediction across diverse racial and ethnic groups.

This study uses Mendelian randomization to show that higher physical activity levels are associated with lower risks of breast and colorectal cancer.