Li Li

This study shows that prior respiratory viral infections like SARS-CoV-2 or influenza accelerate lung tumor growth by altering the immune environment and promoting a pro-tumor microenvironment.

This study integrates large-scale omics and electronic health records to identify risk proteins and drugs for cancer prevention, finding 101 novel proteins and three drugs associated with reduced colorectal cancer risk.

The paper introduces pathway-based polygenic risk scores (pPRS) to detect gene-environment interactions, finding a significant interaction between NSAIDs and the TGF-β/GRHR pathway in colorectal cancer.

The paper identifies tissue-specific DNA methylation biomarkers for cancer risk by integrating genome and epigenome data from the GTEx consortium and GWAS data.

The paper identifies fructose-associated DNA methylation changes in AA colon tissue linked to CRC risk, showing greater effects in right-side colon.

This study improves polygenic risk scores for colorectal cancer by combining Asian and European ancestry data, enhancing risk prediction across diverse racial and ethnic groups.

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.

This study uses Mendelian randomization to show that higher physical activity levels are associated with lower risks of breast and colorectal cancer.