W. James Gauderman

The paper identifies genetic associations with perivascular space morphology in children using MRI and genomics data from the Adolescent Brain Cognitive Development Study.

SNPWay provides a streamlined workflow for SNP-to-function and pathway over-representation analysis using integrated tools and a web server.

The paper benchmarks SNP annotation tools and gene models across the genome, showing discrepancies in annotation and their impact on pathway analysis.

The paper uses pathway-specific polygenic scores to identify gene-adiposity interactions affecting liver biomarkers, finding more specific and interpretable results compared to standard polygenic scores and GWIS.

The paper introduces pathway-based polygenic risk scores (pPRS) to detect gene-environment interactions, finding a significant interaction between NSAIDs and the TGF-β/GRHR pathway in colorectal cancer.

The paper identifies novel genetic loci associated with systolic blood pressure that interact with the DASH diet score through genome-wide interaction analysis.

The paper improves two-step tests for gene-environment interactions by addressing displacement issues and multiple testing, showing increased power in simulations and a GxSex interaction in colorectal cancer.

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.

The paper proposes a two-step method to detect gene-environment interactions across multiple phenotypes, showing improved power in simulations and identifying significant signals in lipid data from UK Biobank.

The paper analyzes gene-environment interaction effects across multiple ancestries and traits, identifying population-specific genetic mechanisms and methodological biases in GxE studies.

The paper uses gene co-expression networks in whole blood to identify molecular pathways associated with obese asthma, finding four modules linked to obesity and enriched for inflammatory pathways.