Jette Steinbach

LT-FGRS estimates genetic liabilities from large-scale family data, unifying methods into an R package for efficient population-scale analysis.

The paper shows genotype- and phenotype-based genetic instruments explain largely independent components of liability to psychiatric disorders, supported by theoretical analysis and simulations.

ADuLT is a time-to-event GWAS method that outperforms Cox regression in strongly ascertained studies, finding more genome-wide significant associations in psychiatric disorder analyses.

The paper introduces PA-FGRS, a method to estimate genetic liability from family records, and shows it improves MDD classification and GWAS power when combined with genotypes.