Vivek Appadurai

The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.

The paper shows genotype- and phenotype-based genetic instruments explain largely independent components of liability to psychiatric disorders, supported by theoretical analysis and simulations.

Polygenic analyses show important differences between MDD symptoms collected using PHQ9 and CIDI-SF

The paper shows that PHQ9 and CIDI-SF MDD symptoms have low to moderate genetic correlations, with distinct associations to dysphoria and symptom heterogeneity.

PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorder

The paper introduces PA-FGRS, a method to estimate genetic liability from family records, and shows it improves MDD classification and GWAS power when combined with genotypes.

Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks

The paper evaluates how haplotype estimation and whole genome imputation accuracy vary with data integration protocols and phasing methods in a large psychiatric biobank dataset.

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

This study identifies genetic overlaps between psychiatric disorders, language ability, and creativity through a GWAS of school grades.

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD

This paper improves genetic studies of MDD by integrating shallow and deep phenotypes, enhancing GWAS power and PRS accuracy while preserving specificity.

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample

The paper investigates genome-wide interactions between stressful life events and depression using a case-cohort study, identifying three genome-wide significant loci but lacking replication in an independent sample.

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

This study identifies seven new genetic loci associated with febrile seizures, linking them to fever response and neuronal excitability genes, and suggests potential clinical applications of polygenic risk scores.

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders - findings from a Danish population-based study

This study identifies a bidirectional association between autoimmune and mental disorders using Danish population data and finds HLA loci linked to autoimmune diseases but not mental disorders.

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

This study identifies four novel genetic loci associated with multiple psychiatric disorders, implicating fetal neurodevelopment as a key mediator of shared genetic risk.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.