Author

Henrik Ohlsson

Lund UniversityORCID 0000-0002-2946-4859Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:GWAS summary statistics· 3 Organism:human· 3 Research Focus:benchmarking· 2 Research Focus:polygenic risk· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Andrew Joseph SchorkiD· 4 shared Bjarni Jóhann VilhjálmssoniD· 4 shared Kenneth S. KendleriD· 4 shared Morten Dybdahl KrebsiD· 4 shared Emil M. PederseniD· 3 shared Jette SteinbachiD· 3 shared Kajsa-Lotta Georgii HellbergiD· 3 shared Thomas Mears WergeiD· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Andrew Joseph SchorkORCID

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4 papers

Recent·Most cited

LT-FGRS: a unifying R-package for the estimation of family-based genetic liabilities at population-scale

Emil M. Pedersen, Jette Steinbach, Mathias Valstad, Henrik Ohlsson, Lucas Rasmussen, Espen Moen Eilertsen, Kenneth S. Kendler, Bjarni Jóhann Vilhjálmsson, Andrew Joseph Schork, Morten Dybdahl Krebs

LT-FGRS estimates genetic liabilities from large-scale family data, unifying methods into an R package for efficient population-scale analysis.

bioRxiv · Jun 19, 2026 · PreprintGenetics

The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.

Morten Dybdahl Krebs, Vivek Appadurai, Kajsa-Lotta Georgii Hellberg, Henrik Ohlsson, Jette Steinbach, Emil M. Pedersen, Thomas Mears Werge, Jan Sundquist, Kristina Sundquist, Richard Border, Na Cai, Noah Zaitlen, Andy W. Dahl, Bjarni Jóhann Vilhjálmsson, Jonathan Flint C, , Andrew Joseph Schork

The paper shows genotype- and phenotype-based genetic instruments explain largely independent components of liability to psychiatric disorders, supported by theoretical analysis and simulations.

The American Journal of Human Genetics · Dec 22, 2025Peer-reviewedGenetic & Genomic Medicine

As rates of ASD and ADHD rise, genetic contributions fall: Evidence for widening diagnostic criteria

Sonja LaBianca, Mette Lise Lousdal, Morten Dybdahl Krebs, Ole S Hansen, Kajsa-Lotta Georgii Hellberg, Mischa Lundberg, Johanne Østerby Sørensen, Jesper R. Gådin, Henrik Ohlsson, Anders Dupont Børglum, Esben Agerbo, Thomas Mears Werge, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Kenneth S. Kendler, , Andrew Joseph Schork

This study shows that as ASD and ADHD diagnoses have increased, the genetic risk associated with these conditions has decreased over time.

medRxiv · Nov 10, 2025 · PreprintGenetic & Genomic Medicine

PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorder

Morten Dybdahl Krebs, Kajsa-Lotta Georgii Hellberg, Mischa Lundberg, Vivek Appadurai, Henrik Ohlsson, Emil M. Pedersen, Jette Steinbach, Jamie Matthews, Sonja LaBianca, Xabier Calle, Joeri J. Meijsen, Andrés Ingason, Alfonso Buil, Bjarni Jóhann Vilhjálmsson, Jonathan Flint C, , Andrew Joseph Schork

The paper introduces PA-FGRS, a method to estimate genetic liability from family records, and shows it improves MDD classification and GWAS power when combined with genotypes.

medRxiv · Jun 23, 2023 · PreprintGenetic & Genomic Medicine