Birte Hernandez Alvarez

This paper expands the known ligand space of Cereblon by identifying new chemically distinct ligands that bind through non-canonical mechanisms.

This study characterizes HLp, a bacterial histone that forms tetramers and wraps ~60 base pairs of DNA, revealing a new mode of histone-DNA interaction in bacteria.

This study shows that the archaeal histone HTkC forms highly compact DNA structures, doubling the compaction level of hypernucleosomes and highlighting its role in chromatin organization.

This study investigates the DNA-binding properties of bacterial histone HBb in Bdellovibrio bacteriovorus, revealing its ability to bend DNA in a sequence-independent manner, similar to archaeal and eukaryotic histones.

The paper uses AlphaFold2 to classify prokaryotic histones into 17 groups and identifies a new histone superfamily that bridges DNA instead of wrapping it.