BioinformaticsCellPeer-reviewed
A Modular Master Regulator Landscape Determines the Impact of Genetic Alterations on the Transcriptional Identity of Cancer Cells
Evan Paull, Àlvaro Aytés, Sunny J. Jones…·Andrea Califano
The paper identifies 407 Master-Regulator proteins that canalize cancer genomics into transcriptional subtypes and links genetic alterations to tumor biology through modular regulatory architectures.
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