A Modular Master Regulator Landscape Determines the Impact of Genetic Alterations on the Transcriptional Identity of Cancer Cells
Evan Paull, Àlvaro Aytés, Sunny J. Jones, Prem S. Subramaniam, Federico Manuel Giorgi, Eugene F. Douglass, Somnath Tagore, Brennan Chu, Alessandro Vasciaveo, Siyuan Zheng, Roel G.W. Verhaak, Cory T. Abate-Shen, Mariano J. Alvarez, Andrea Califano
The paper identifies 407 Master-Regulator proteins that canalize cancer genomics into transcriptional subtypes and links genetic alterations to tumor biology through modular regulatory architectures.
Cell · Jan 1, 2021Peer-reviewedBioinformatics