Sunny J. Jones

Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control

The paper uses CRISPRi and single-cell RNA-seq to reverse engineer gene regulatory networks in colorectal cancer cells, revealing autoregulatory and cooperative mechanisms.

A Modular Master Regulator Landscape Determines the Impact of Genetic Alterations on the Transcriptional Identity of Cancer Cells

The paper identifies 407 Master-Regulator proteins that canalize cancer genomics into transcriptional subtypes and links genetic alterations to tumor biology through modular regulatory architectures.

Systematic Elucidation and Validation of OncoProtein-Centric Molecular Interaction Maps

The paper introduces an algorithm to reconstruct context-specific molecular interaction maps centered on oncoproteins, validating it with KRAS in lung adenocarcinoma and identifying novel synthetic lethal proteins.