Saba Ghaffari

This paper introduces Somatic-IV, a method to identify candidate driver genes in cancer by integrating genetic, transcriptomic, and clinical data, and finds ZBED2 and CSNK2A2 as potential drivers in pancreatic and colorectal cancers.

BEDwARS improves bulk gene expression deconvolution by estimating cell type proportions and signatures simultaneously, showing robustness to noisy references and identifying mechanisms in a rare pediatric condition.