Inhibition of macrophage neuraminidase 1 protects against immune thrombocytopenia by limiting platelet clearance
Antoine Caillon, Lorena Carvelli, Xuefang Pan, Diogo R. Poroca, Silvia Neri, Elisa G. Carvajal, Aymeric Fabié, Manon Saby, Yves Dominique Pastore, Renée Bazin, Thomas Pincez, Christopher W. Cairo, Alexey V. Pshezhetsky
This study shows that inhibiting macrophage NEU1 reduces platelet clearance in ITP by limiting phagocytosis, suggesting NEU1 as a therapeutic target.
bioRxiv · Sep 7, 2026 · PreprintBiochemistry