Jose Ignacio Lopez

The paper quantifies the information capacity of DNA methylation using Shannon information theory to estimate its role as an epigenetic identity code.

The paper quantifies the information capacity of post-translational modifications (PTMs) on human RNA polymerase II, distinguishing theoretical maximum from physiologically achievable regulatory capacity.

This study analyzes PTEN-deficient prostate tumors to reveal stromal reprogramming and senescent paracrine communication through transcriptional network analysis and single-cell RNA-Seq.

This study investigates the migratory behavior of enucleated and non-enucleated cells, showing that locomotion is regulated by systemic, self-organized dynamics.

The paper quantitatively analyzes cell migration trajectories across species and stimuli, finding that directional movement results from systemic, integrative cellular processes rather than individual molecular components.

This study examines associative conditioning in three amoeba species, finding robust conditioned migration patterns with directional persistence across species.

This study demonstrates associative memory in Amoeba proteus by linking a conditioned stimulus (electric field) with a non-conditioned stimulus (chemotactic peptide), showing learned systemic motility patterns.