Isabel Mendizabal

eRREMS expands regulatory CpG coverage in reduced representation methylome sequencing

eRREMS improves CpG coverage in methylome sequencing by combining MspI and HaeIII digestion, outperforming RRBS and WGBS in capturing regulatory CpGs.

A pan-cancer single-cell atlas of pericytes

The paper constructs a pan-cancer single-cell RNA sequencing atlas of pericytes, revealing a common transcriptional program in tumour-associated pericytes and their specialised subtypes across multiple cancers.

Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

This study analyzes PTEN-deficient prostate tumors to reveal stromal reprogramming and senescent paracrine communication through transcriptional network analysis and single-cell RNA-Seq.

The transcriptional landscape of metastatic hormone-naive prostate cancer

This study characterizes the transcriptome of metastatic hormone-naive prostate cancer, identifying stroma remodelling and SOX11's role in metastasis.

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

Transcription factor 19 is an androgen responsive gene that modulates vessel homeostasis and sustains metastatic prostate cancer

The paper identifies TCF19 as an androgen-responsive gene upregulated in metastatic prostate cancer, showing its role in vessel homeostasis and metastatic progression.

Human Brain Aging is Associated with Dysregulation of Cell-Type Epigenetic Identity

This study identifies age-related DNA methylation changes in neurons and oligodendrocytes, showing that epigenetic drift is a stronger predictor of methylation variation than sex or disease.

DNA methylation differences between the female and male X chromosomes in human brain

The paper examines DNA methylation differences between female and male X chromosomes in human brain cells using whole genome bisulfite sequencing, revealing global hypomethylation on female X chromosomes and promoter-specific hypermethylation.

Cell-type and cytosine context-specific evolution of DNA methylation in the human brain

The paper investigates DNA methylation evolution in human brain cells, showing reduced CG methylation and increased CH methylation, linked to schizophrenia risk.

Cell-type specific epigenetic links to schizophrenia risk in brain

The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.