Michael Georgieff

Hierarchical Transcriptomic and Epigenetic Recovery and Remodeling in the Developing Hippocampus Following Early-life Environmental Insults: An Iron Deficiency Rat Model

This study examines transcriptomic and epigenetic changes in rat hippocampi after developmental iron deficiency and postnatal iron treatment, showing partial epigenetic recovery and new modifications.

Iron Deficiency Impairs Mitochondrial Energetics and Early Axonal Growth and Branching in Developing Hippocampal Neurons

This study shows iron deficiency impairs mitochondrial function and early axon growth in hippocampal neurons, linking iron-dependent energy production to axonal development.

Neonatal phlebotomy-induced anemia compromises mitochondrial bioenergetics in the developing hippocampus

This study shows that neonatal phlebotomy-induced anemia reduces mitochondrial oxygen consumption and ETC complex function in the hippocampus, impairing energy-demanding neurodevelopmental processes.

Utility of brain-derived extracellular vesicles from human umbilical cord blood to measure non-infectious neuroinflammation and functional iron deficiency

This study isolates and analyzes brain-derived extracellular vesicles from umbilical cord blood to detect non-infectious neuroinflammation and neonatal iron deficiency in infants.

Cellular Iron Deficiency Disrupts Thyroid Hormone Regulated Gene Expression in Developing Hippocampal Neurons

This study shows neuronal iron deficiency disrupts thyroid hormone-regulated gene expression in developing hippocampal neurons, with some effects persisting after iron repletion.

Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome

This study examines sex-specific transcriptome changes in adult rat hippocampus due to early-life iron deficiency and prenatal choline treatment, finding greater effects in females.

ATAC and histone H3K9me3 landscapes revealed the altered epigenome by fetal-neonatal iron deficiency in the adult male rat hippocampus

This study examines how fetal-neonatal iron deficiency and prenatal choline supplementation affect epigenetic marks in adult rat hippocampi, revealing altered chromatin accessibility and H3K9me3 enrichment linked to gene dysregulation.