Author

Tomas Babak

Queen's UniversityORCID 0000-0003-0879-0134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Michael VermeuleniD· 2 shared Andrew W. CraigiD· 1 shared Brian DeVealeiD· 1 shared Micheal Rollins-GreeniD· 1 shared Zhongshan ChengiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersCancer Biology

Michael VermeulenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 20, 2025

Challenges and opportunities for drug repurposing in cancers based on synthetic lethality induced by tumor suppressor gene mutations

Michael Vermeulen, Andrew W. Craig, Tomas Babak

This paper identifies potential drug repurposing opportunities through synthetic lethality by analyzing CRISPR screens and drug sensitivity data, but finds pharmacological inhibitors often fail to mimic genetic KO effects.

3 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 29, 2019

A catalog of cis-regulatory mutations in 12 major cancer types

Zhongshan Cheng, Michael Vermeulen, Micheal Rollins-Green…·Tomas Babak

The paper identifies 301 non-coding somatic mutations affecting gene expression in 12 cancer types using TCGA data and shows they have features of noncoding drivers.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky