Michael Vermeulen

This paper identifies potential drug repurposing opportunities through synthetic lethality by analyzing CRISPR screens and drug sensitivity data, but finds pharmacological inhibitors often fail to mimic genetic KO effects.

The paper quantifies mosaic loss of chromosome Y (LOY) in brain cells across multiple datasets and finds microglia are most affected by LOY, with associated gene expression changes linked to aging and neurodegeneration.

The paper identifies 301 non-coding somatic mutations affecting gene expression in 12 cancer types using TCGA data and shows they have features of noncoding drivers.