Author
Institute for Research in BiomedicineORCID 0000-0003-0880-8904Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Ignasi Toledano, Fran Supek, Ben Lehner
This study quantifies sequence determinants of human programmed stop codon readthrough using deep mutational scanning and identifies gene-specific and context-dependent effects.
Marcell Veiner, Ignasi Toledano, Guillermo Palou-Márquez…·Fran Supek
The paper develops a model to predict nonsense-mediated mRNA decay (NMD) across human genes using genomic data and mutational scanning, showing improved accuracy and revealing quantitative rules of NMD implementation.
Ignasi Toledano, Fran Supek, Ben Lehner
The paper quantifies and predicts pathogenic stop codon readthrough by small molecules across ~5,800 human PTCs using 8 drugs, revealing drug-specific readthrough patterns and building predictive models.
Taylor L. Mighell, Ignasi Toledano, Ben Lehner
The paper introduces SUNi mutagenesis, a method for generating variant libraries with high scalability and uniformity to enable MAVEs of gene families and genomes.