Bradley Peter

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

This study characterizes the molecular pathogenesis of a POLG mutation by showing how it impairs POLγA function and leads to mtDNA instability through LONP1-dependent degradation.