Aleksandra Trifunović

A Neuronally Active Bacterial Siderophore Manipulates Host Behavior and Longevity

This study identifies bacterial enterobactin as a non-canonical neurotransmitter that modulates host behavior and aging via mitochondrial function and redox state.

Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

Male obesity causes adipose mitochondrial dysfunction in F1 progeny via a let-7-DICER axis.

This study shows that male obesity affects adipose mitochondrial function in offspring via the let-7-DICER axis, with reversible effects observed in both mice and human semen.

Topology control by a conserved cysteine pair in the OMM-protein CCDC127 enables MICOS interaction

The paper identifies CCDC127 as a mitochondrial disulfide relay substrate that interacts with MICOS components, revealing its role in OMM topology and mitochondrial membrane organization.

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

SPTF-3/SP1 orchestrates mitochondrial biogenesis upon ribosomal stress and acute starvation

The paper identifies SPTF-3 as a stress-induced transcription factor regulating mitochondrial biogenesis and UPRmt in C. elegans, with its mammalian homolog SP1 showing conserved function in nutrient deprivation.

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.

In vivo and in vitro mechanistic characterization of a clinically relevant PolγA mutation

This study characterizes the molecular pathogenesis of a POLG mutation by showing how it impairs POLγA function and leads to mtDNA instability through LONP1-dependent degradation.

Alterations of redox and iron metabolism accompany development of HIV latency.

The paper identifies alterations in redox and iron metabolism associated with HIV-1 latency development and suggests iron metabolism modulators as potential therapeutic tools.