Rebecca E. Jarvis

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.