MicrobiologyJCI InsightPeer-reviewed
Activation of bradykinin receptor B1 promotes desensitization of CXCR2 in neutrophils during severe sepsis and contributes to disease progression in mice.
Raquel Duque do Nascimento Arifa, Carolina B R Mascarenhas, Lívia C R Rossi…·Daniele G Souza
This study shows that BDKRB1 activation worsens sepsis by impairing neutrophil migration and CXCR2 function, and inhibiting BDKRB1 improves survival and bacterial clearance in mice.
3 citations