Adriana Figueroa Garcia

Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model

This study shows that mitochondrial dysfunction contributes to premature musculoskeletal aging in HCH mice, with proteomics revealing altered aging trajectories and bone fragility.

APP metabolism is regulated by p97/VCP through an autophagy and endolysosome-dependent mechanism

This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinsons disease

The paper identifies urinary protein signatures linked to LRRK2 dysfunction in Parkinson's disease using multi-cohort proteomics and machine learning, showing cross-species relevance and potential as pharmacodynamic markers.