Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukaemia patients
Anil Kumar Giri, Jake Lin, Konstantinos Kyriakidis…·Henrikki Almusa
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University of HelsinkiORCID 0000-0003-0941-1458Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
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Anil Kumar Giri, Jake Lin, Konstantinos Kyriakidis…·Henrikki Almusa
Aleksandr Ianevski, Kristen Michelle Nader, Kyriaki Driva…·Tero A. Aittokallio
The paper develops a machine learning model to identify patient-specific multi-targeting therapies using single-cell transcriptomic data for hematological cancers and solid tumors.
Aleksandr Ianevski, Anil Kumar Giri, Tero A. Aittokallio
ScType automates cell-type identification from scRNA-seq data using marker genes, achieving accurate and unbiased annotations across human and mouse tissues.
Anil Kumar Giri, Gauri Prasad, Vaisak Parekatt…·Dwaipayan Bharadwaj
The paper identifies DNA methylation signatures and risk modules associated with T2DM using EWAS and network analysis, revealing JUP as a regulator of a co-methylated risk module.
Aleksandr Ianevski, Jenni Lahtela, Komal Kumar Javarappa…·Tero A. Aittokallio
This paper develops a computational-experimental approach to design patient-specific drug combinations for AML that are synergistic and minimally toxic.
INDICO, Anil Kumar Giri, Gauri Prasad…·Dwaipayan Bharadwaj
This study identifies novel genetic loci associated with BMI in Indians through GWAS and explores their epigenetic and regulatory mechanisms.
Aleksandr Ianevski, Alexander Kononov, Sanna H. Timonen…·Anil Kumar Giri
SynToxProfiler prioritizes drug combinations by integrating synergy, efficacy, and toxicity profiles to improve clinical success likelihood.