Mark E. J. Sheffield

The paper shows that right CA3 inputs drive early spatial map refinement in CA1R, while left CA3 inputs ensure stability later, with a shift in dominance during learning.

This study shows that hippocampal representational drift can be controlled by manipulating dentate gyrus granule cells, revealing it is actively regulated by circuit inputs rather than being intrinsic.

The paper introduces a preprocessing pipeline for 2-photon calcium imaging to improve subcellular signal detection and ROI grouping.

The paper identifies Behavioral-Timescale-Synaptic-Plasticity (BTSP) as the mechanism driving hippocampal place field shifts during familiarization, contrasting it with Spike-Timing-Dependent-Plasticity.

This paper develops a virtual reality-based contextual fear conditioning paradigm for head-fixed mice, demonstrating freezing behavior and hippocampal CA1 neuron remapping similar to freely moving animals.

The paper examines how VTA and LC catecholaminergic pathways in the hippocampal CA1 region differ in their activity during navigation in familiar and novel environments.

This study shows that reward expectation reduces representational drift in the hippocampus by maintaining reliable place fields across days.

The paper shows that lower spatial precision in place cells during an episode predicts remapping or vanishing of place fields in subsequent episodes.

The paper investigates the role of the NR-CA1 pathway in contextual fear memory retrieval, finding that it suppresses fear responses by disrupting memory retrieval.

This study uses electron microscopy to analyze dopaminergic axon connections in the Nucleus Accumbens before and after cocaine exposure, revealing non-synaptic communication and axonal remodeling.

This study compares place cell dynamics in CA1 and CA3 of mice during familiarization with new environments, finding distinct patterns of field emergence and stability.

This study shows that reward expectation alters place cell dynamics and enhances spatial memory encoding and retrieval in the hippocampus.