Author

Ronan Depoortère

Neurolixis (United States)ORCID 0000-0003-0970-420XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:rat· 1

Frequent Co-Authors

Adrian Newman‐TancrediiD· 3 shared Lucy E. AnnettiD· 1 shared Mahmoud M. IravaniiD· 1 shared Michael R. Tranfaglia· 1 shared William H. Powell· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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3 shared papersNeuroscience

Adrian Newman‐TancrediORCID

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3 papers

Recent·Most cited

NeuroscienceProgress in Neuro-Psychopharmacology and Biological PsychiatryPeer-reviewedMar 22, 2026

The selective 5-HT1A receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndrome

Ronan Depoortère, Michael R. Tranfaglia, Adrian Newman‐Tancredi

NLX-101, a 5-HT1A receptor biased agonist, improves multiple behavioral and cognitive deficits in FMR1 KO2 mice, showing dose-dependent effects.

DOI 10.1016/j.pnpbp.2026.111681

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 5, 2025

The 5-HT1A receptor selective agonist NLX-204 displays analgesic activity in the knee osteoarthritis and plantar incisional post-operative pain models in rats

Ronan Depoortère, Adrian Newman‐Tancredi

This study evaluates the analgesic effects of NLX-204, a 5-HT1A receptor agonist, in rat models of osteoarthritis and post-operative pain, showing dose-dependent pain relief compared to morphine.

DOI 10.64898/2025.12.02.691847

ratexperimental assay

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Pharmacology & ToxicologybioRxivPreprintSep 25, 2025

NLX-112 is anti-inflammatory, upregulates GDNF and is neuroprotective against MPTP-induced nigrostriatal dopaminergic degeneration in mice

William H. Powell, Lucy E. Annett, Ronan Depoortère…·Mahmoud M. Iravani

This study shows NLX-112 protects against MPTP-induced dopaminergic neuron loss in mice by reducing microgliosis, increasing GDNF, and improving locomotor activity.

DOI 10.1101/2025.09.25.678507

𝕏 PostBluesky