Ingo Burtscher

This paper introduces a dual-gastruloid model to study the co-development of foregut-pharyngeal mesoderm in mice, showing the role of Foxa2 in Tbx1 expression.

The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.

This paper introduces MIRACLES, a method to image cell membrane potential dynamics using vibrational optoacoustic detection, and demonstrates its application in monitoring glucose-stimulated insulin secretion in beta-cells.

This study identifies Synaptotagmin 13 as a key regulator of endocrine cell egression and islet formation through its role in cell polarity and basement membrane remodeling.

This paper generates a Nkx6-1 Venus fusion reporter mouse line to track and isolate Nkx6-1-expressing cells, including pancreatic β-cells, during development and in adult tissues.

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.

This study shows that Foxa2 binding site selection is influenced by chromatin environment and that chromatin opening requires collaboration with other transcription factors during endoderm differentiation.