Author

Alex L. Bortvin

Carnegie Institution for ScienceORCID 0000-0003-0987-1905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Chiara De LucaiD· 2 shared Anuj Kumar GuptaiD· 1 shared Brendan MilleriD· 1 shared Godfried W. van der HeijdeniD· 1 shared Kasper D. HanseniD· 1 shared Marla E. TharpiD· 1 shared Safia MalkiiD· 1 shared Valeriya A. Gaysinskaya· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 12 mutual co-author links

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2 shared papersMolecular Biology

Chiara De LucaORCID

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3 papers

Recent·Most cited

Molecular BiologyPLoS GeneticsPeer-reviewedJun 12, 2023

Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes

Chiara De Luca, Anuj Kumar Gupta, Alex L. Bortvin

The paper investigates how ORF1p-driven ribonucleoprotein condensates sustain RNA integrity and translation in mouse spermatocytes despite interactions with RNA regulators.

20 citations

mousemultiome

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Developmental BiologybioRxivPreprintJun 3, 2019

Evading non-essential fetal oocyte attrition maximizes the ovarian reserve

Marla E. Tharp, Safia Malki, Alex L. Bortvin

The paper shows that inhibiting L1 reverse transcriptase and the Chk2 checkpoint prevents fetal oocyte attrition, preserving the ovarian reserve.

1 citation

mousehuman

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Molecular BiologyEpigenetics & ChromatinPeer-reviewedApr 4, 2018

Transient Reduction of DNA Methylation at the Onset of Meiosis in Male Mice

Valeriya A. Gaysinskaya, Brendan Miller, Chiara De Luca…·Alex L. Bortvin

The paper identifies a transient reduction of DNA methylation during early meiosis in male mice, linked to retrotransposon expression and meiotic processes.

74 citations

mouseDNA methylation

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