Brendan Miller

The Integration of Proteogenomics and Ribosome Profiling Circumvents Key Limitations to Increase the Coverage and Confidence of Novel Microproteins

This paper introduces RP3, a pipeline combining proteogenomics and ribosome profiling to identify microprotein-encoding smORFs missed by Ribo-Seq alone, improving detection and confidence.

A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-c

The paper identifies a mtDNA polymorphism in MOTS-c associated with increased T2D risk in males, interacting with physical activity.

Improving the clinical performance of blood-based DNA methylation biomarkers utilizing locus-specific epigenetic heterogeneity

This paper develops EpiClass, a methylation density-based classifier that improves the performance of blood-based DNA methylation biomarkers in detecting ovarian cancer by leveraging locus-specific epigenetic heterogeneity.

Transient Reduction of DNA Methylation at the Onset of Meiosis in Male Mice

The paper identifies a transient reduction of DNA methylation during early meiosis in male mice, linked to retrotransposon expression and meiotic processes.