Author

Christer Sylvén

Karolinska InstitutetORCID 0000-0003-1017-7849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Ludvig LarssoniD· 2 shared Mats F. NilssoniD· 2 shared Sergio Marco SalasiD· 2 shared Agneta Månsson‐BrobergiD· 1 shared Åsa K. BjörklundiD· 1 shared Carolina WählbyiD· 1 shared Christophe AveneliD· 1 shared Emelie BrauniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersDevelopmental Biology

Ludvig LarssonORCID

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3 papers

Recent·Most cited

Spatial Dynamics of the Developing Human Heart

Enikő Lázár, Raphaël Mauron, Žaneta Andrusivová, Julia Foyer, Mengxiao He, Ludvig Larsson, Nick Shakari, Sergio Marco Salas, Christophe Avenel, Sanem Sarıyar, Jan N. Hansen, Marco Vicari, Paulo Czarnewski, Emelie Braun, Xiaofei Li, , Joakim Lundeberg

This study maps spatial dynamics in early human heart development using single-cell and spatial transcriptomics, identifying cell states and novel features like cardiac fibroblasts and chromaffin cells.

Nature Genetics · Oct 29, 2025Peer-reviewedDevelopmental Biology

High cardiomyocyte diversity in human early prenatal heart development

Christer Sylvén, Eva Wärdell, Agneta Månsson‐Broberg, Eugenio Cingolani, Konstantinos Ampatzis, Ludvig Larsson, Åsa K. Björklund, Stefania Giacomello

The paper characterizes human prenatal cardiomyocytes using single-cell RNA sequencing and spatial transcriptomics, identifying eight distinct types with location-dependent properties and ligand-receptor interactions.

iScience · Dec 20, 2022Peer-reviewedSystems Biology

De novo spatiotemporal modelling of cell-type signatures identifies novel cell populations in the developmental human heart

Sergio Marco Salas, Xiao Yuan, Christer Sylvén, Mats F. Nilsson, Carolina Wählby, Gabriele Partel

The paper uses a de novo spatial modeling approach to identify novel cell populations in the developing human heart, revealing previously unreported molecular diversity.

bioRxiv · Jul 10, 2021 · PreprintDevelopmental Biology