Raphaël Mauron

In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme

The paper uses in utero barcoding and single-cell transcriptomics to map clonal relationships in mouse mesoderm-derived tissues, revealing lineage relationships in liver and heart mesenchyme.

Highly resolved tumor architecture via matched spatial and nucleus transcriptomics from a single tissue section

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

Dissecting human fetal cardiac repair using cardioids

This study uses a human cardioid injury platform to investigate immune-ECM-cardiomyocyte interactions in fetal cardiac repair, identifying key signaling pathways and cellular behaviors involved in regeneration.

Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve

The paper identifies rare gain-of-function regulatory mutations as significant contributors to the missing heritability of bicuspid aortic valve.

Spatial Dynamics of the Developing Human Heart

This study maps spatial dynamics in early human heart development using single-cell and spatial transcriptomics, identifying cell states and novel features like cardiac fibroblasts and chromaffin cells.