Yang Li

This paper presents the crystal structure of an engineered TdT variant and shows how mutations alter substrate specificity to accommodate bulky DNA terminators.

This paper reports the crystal structures of an antibody used in CoolMPS sequencing, revealing the structural basis for its high specificity in recognizing modified nucleotides.

This paper introduces a scalable batch-correction method for integrating large-scale single-cell transcriptomes and shows it matches state-of-the-art performance on 18 million cells from the Human Cell Atlas.

The paper introduces tGPT, a generative model for integrating large-scale single-cell transcriptomes, showing its effectiveness in clustering, trajectory inference, and linking gene patterns to clinical outcomes.