Jianxun Qi

Structural Insights into Single-Stranded DNA Recognition and Modified Substrate Tolerance in an Engineered Terminal Deoxynucleotidyl Transferase

This paper presents the crystal structure of an engineered TdT variant and shows how mutations alter substrate specificity to accommodate bulky DNA terminators.

Structural Mechanism of Specific Nucleobase Recognition by a Monoclonal Antibody in CoolMPSTM Sequencing

This paper reports the crystal structures of an antibody used in CoolMPS sequencing, revealing the structural basis for its high specificity in recognizing modified nucleotides.

C-Reactive Protein Drives Potent Clearance of Blood Bacteria in the Liver by Activating the Complement System

This study shows CRP helps liver macrophages capture and eliminate blood bacteria by activating the complement system, enhancing immune response.

Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms

This study designs and tests dimeric RSV F-subunit vaccines in protein and mRNA forms, showing enhanced immunogenicity and protection against RSV infection in rodent models.

Designing a broad-spectrum four-helix bundle targeting different strains of SARS-CoV-2 Spike Receptor Binding Domains with ACE2-like binding interface

The paper designs a protein that binds to multiple SARS-CoV-2 RBD variants with high affinity, demonstrating a strategy for broad-spectrum antiviral inhibitors.