Author

Lauren K. Brais

Broad InstituteORCID 0000-0003-1069-0407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander Chowdhury· 1 shared Alexandra Franz· 1 shared Amalie Dahl HaueiD· 1 shared Amanda GarzaiD· 1 shared Aviv RegeviD· 1 shared Bo YuaniD· 1 shared Breanna M. TitcheniD· 1 shared Brian Matthew WolpiniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Alexander Chowdhury

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2 papers

Recent·Most cited

Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors

Julie Karam, Samantha E. Hoffman, Amanda Garza, Dan Y. Gui, Hannah I. Hoffman, Breanna M. Titchen, Yutaro Tanaka, Erica Maria Pimenta, Θεοδώρα Παππά, Laura Valderrábano, Kevin Bi, Riaz Gillani, Lauren K. Brais, Erin E. Shannon, Jason L. Hornick, , Eliezer M. Van Allen

This study identifies conserved neuronal-like and secretory programs in GEP-NETs and links them to spatial microenvironmental niches and metastatic potential.

Journal of Clinical Investigation · Sep 1, 2026Peer-reviewedCancer Biology

Pancreatic cancer risk predicted from disease trajectories using deep learning

Davide Placido, Bo Yuan, Jessica Xin Hjaltelin, Chunlei Zheng, Amalie Dahl Haue, Piotr Jaroslaw Chmura, Chen Yuan, Jihye Kim, Renato Umeton, Gregory C. Antell, Alexander Chowdhury, Alexandra Franz, Lauren K. Brais, Elizabeth Andrews, Debora S. Marks, , Chris Sander

This paper uses deep learning to predict pancreatic cancer risk from clinical disease trajectories in two large datasets, achieving higher accuracy than models without temporal information.

bioRxiv · Jun 27, 2021 · PreprintBioinformatics