Author

Samantha E. Hoffman

Broad InstituteORCID 0000-0002-6752-172XUnclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:clustering· 3 Approach:deep learning· 3 Assay:scRNA-seq· 3 Assay:spatial transcriptomics· 3 Assay:ATAC-seq· 2

Frequent Co-Authors

Amanda GarzaiD· 4 shared Breanna M. TitcheniD· 4 shared Eliezer M. Van AlleniD· 4 shared Jihye ParkiD· 4 shared Kevin BiiD· 4 shared Erica Maria PimentaiD· 3 shared Erin E. ShannoniD· 3 shared Julie Karam· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Amanda GarzaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors

Julie Karam, Samantha E. Hoffman, Amanda Garza, Dan Y. Gui, Hannah I. Hoffman, Breanna M. Titchen, Yutaro Tanaka, Erica Maria Pimenta, Θεοδώρα Παππά, Laura Valderrábano, Kevin Bi, Riaz Gillani, Lauren K. Brais, Erin E. Shannon, Jason L. Hornick, , Eliezer M. Van Allen

This study identifies conserved neuronal-like and secretory programs in GEP-NETs and links them to spatial microenvironmental niches and metastatic potential.

Journal of Clinical Investigation · Sep 1, 2026Peer-reviewedCancer Biology

Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity

Yutaro Tanaka, James J. Morrow, Salvador Casaní-Galdón, Erica Maria Pimenta, Jiayi Li, Byron Butaney, Chadi A. El Farran, Julie Karam, Joshua P. D’Antonio, Kevin Bi, Laura Valderrábano, Sabrina Yvonne Camp, Yun Jee Kang, Shreya Johri, Lester Heredia Gopar, , Riaz Gillani

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

bioRxiv · Jun 12, 2026 · PreprintCancer Biology

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

Erica Maria Pimenta, Amanda Garza, Sabrina Yvonne Camp, Jihye Park, Samantha E. Hoffman, Laura Valderrábano, Jingxin Fu, Kevin Bi, Maximilian Carson, Julie Karam, Breanna M. Titchen, Sofia Medjahed, Melin Janardan Khandekar, Erin E. Shannon, Yun Jee Kang, , Eliezer M. Van Allen

This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.

Science Translational Medicine · Jan 21, 2026Peer-reviewedCancer Biology

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

Josephine Yates, Camille A. Mathey-Andrews, Jihye Park, Amanda Garza, Andréanne Gagné, Samantha E. Hoffman, Kevin Bi, Breanna M. Titchen, Connor J. Hennessey, Joshua Remland, Matthew L. Carnes, Erin E. Shannon, Sabrina Yvonne Camp, Siddhi Balamurali, Shweta Kiran Cavale, , Eliezer M. Van Allen

The paper analyzes multiomic data from primary and metastatic esophageal adenocarcinoma tumors to identify cell states and their spatial interactions, linking them to clinical outcomes.

Cell Reports Medicine · Jun 1, 2025Peer-reviewedCancer Biology