Yutaro Tanaka

The paper identifies clustered structural variant hotspots in osteosarcoma, linking them to oncogenic addiction and plasticity through transcriptional changes and clinical detectability.

This study identifies conserved neuronal-like and secretory programs in GEP-NETs and links them to spatial microenvironmental niches and metastatic potential.

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.