Author

Jason L. Hornick

Brigham and Women's HospitalORCID 0000-0001-6475-8345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Amanda GarzaiD· 2 shared Breanna M. TitcheniD· 2 shared Eliezer M. Van AlleniD· 2 shared Erica Maria PimentaiD· 2 shared Erin E. ShannoniD· 2 shared Jihye ParkiD· 2 shared Julie Karam· 2 shared Kevin BiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Amanda GarzaORCID

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Author profile →

3 papers

Recent·Most cited

Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors

Julie Karam, Samantha E. Hoffman, Amanda Garza, Dan Y. Gui, Hannah I. Hoffman, Breanna M. Titchen, Yutaro Tanaka, Erica Maria Pimenta, Θεοδώρα Παππά, Laura Valderrábano, Kevin Bi, Riaz Gillani, Lauren K. Brais, Erin E. Shannon, Jason L. Hornick, , Eliezer M. Van Allen

This study identifies conserved neuronal-like and secretory programs in GEP-NETs and links them to spatial microenvironmental niches and metastatic potential.

Journal of Clinical Investigation · Sep 1, 2026Peer-reviewedCancer Biology

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

Erica Maria Pimenta, Amanda Garza, Sabrina Yvonne Camp, Jihye Park, Samantha E. Hoffman, Laura Valderrábano, Jingxin Fu, Kevin Bi, Maximilian Carson, Julie Karam, Breanna M. Titchen, Sofia Medjahed, Melin Janardan Khandekar, Erin E. Shannon, Yun Jee Kang, , Eliezer M. Van Allen

This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.

Science Translational Medicine · Jan 21, 2026Peer-reviewedCancer Biology

Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas

Jessica D. St. Laurent, Grace Dydian Xu, Alexander Wang Ying, Bengul Gokbayrak, Ajinkya Patil, João A. Paulo, Kasey S. Cervantes, Shary Yuting Chen, William W. Feng, Akshay Sankar, Daniel D. Samé Guerra, Jun Qi, Dana S. Neel, Jason L. Hornick, David L. Kolin, , Cigall Kadoch

This study identifies shifted mSWI/SNF subcomplex stoichiometry in DDEC/UEC cancers and shows that SMARCA4/2 inhibitors reduce tumor growth and synergize with chemotherapy.

Nature Genetics · Oct 20, 2025Peer-reviewedMolecular Biology