Le Huang

The paper identifies eQTL and sQTL in African American blood cells, finding many rare variants undetected in European ancestry studies and creating an open database for results.

This paper provides a computational protocol for automated CAZyme annotation in microbiome sequencing data using dbCAN, offering publication-quality results and faster local execution.

The paper improves genotype imputation for CF patients using the TOPMed reference panel and a CF-specific imputation panel, enhancing marker coverage and PRS accuracy.

eSCAN improves aggregate association testing in WGS data by integrating enhancer regions, enhancing statistical power and resolution in blood cell trait analysis.

This study prioritizes functional elements of ~148,000 GWAS variants for blood cell traits using a web tool, showing prioritized variants are more likely to be experimentally validated.

The paper identifies novel genetic associations for biomarker traits in non-European UK Biobank populations, highlighting missed signals in European-centric analyses.