K C Rajan

This paper develops new mouse models of HHT by inducing somatic LOH mutations in endothelial cells to study disease progression and therapeutic responses.

This study shows that loss of Zmiz1 in mice causes brain abnormalities and autistic-like behaviors, with molecular changes affecting neurogenesis and synaptic signaling.

This study shows that Zmiz1 is essential for both normal and abnormal angiogenesis in the retina, affecting vascular development and regression in mice.

This study identifies Zmiz1 as a regulator of lymphatic endothelial cell function and Prox1 expression, showing its role in lymphatic vessel development and valve formation.