Author

Yixing Wu

UK Dementia Research InstituteORCID 0000-0003-1150-9948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Frances K. WisemaniD· 3 shared Karen CleverleyiD· 3 shared Elizabeth FisheriD· 2 shared Suzanna NoyiD· 2 shared Alicja Mrzyglod· 1 shared Dinghao LuoiD· 1 shared Floris J. van DaleniD· 1 shared Heather T. WhittakeriD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Frances K. WisemanORCID

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3 papers

Recent·Most cited

NeurosciencePLoS ONEPeer-reviewedJan 22, 2025

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy21 human cellular and mouse models

Yixing Wu, Karen Cleverley, Frances K. Wiseman

The paper investigates the effect of reducing Cystatin B on Cathepsin B activity in trisomy 21 models, finding increased activity in disomic controls but not in trisomy 21 conditions.

1 citation

humanmouse

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedAug 14, 2023

Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B

Yixing Wu, Paige Mumford, Suzanna Noy…·Frances K. Wiseman

The paper investigates the impact of elevated cystatin B on cathepsin B activity and microglial localization in Alzheimer's disease in Down syndrome and early-onset Alzheimer's disease.

16 citations

humanmouse

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NeurosciencePLoS ONEPeer-reviewedJul 22, 2021

The effects of CSTB duplication on APP/amyloid-β pathology and cathepsin activity in a mouse model

Yixing Wu, Heather T. Whittaker, Suzanna Noy…·Frances K. Wiseman

This study investigates the effect of Cstb duplication on amyloid-β pathology and cathepsin activity in a mouse model of Alzheimer's disease, finding no significant impact on Aβ levels or cathepsin activity.

6 citations

mouseexperimental assay

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