Suzanna Noy

Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B

The paper investigates the impact of elevated cystatin B on cathepsin B activity and microglial localization in Alzheimer's disease in Down syndrome and early-onset Alzheimer's disease.

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21

This study identifies chromosome 21 genes other than APP that modulate amyloid-β accumulation in Down syndrome mouse models.

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

The effects of CSTB duplication on APP/amyloid-β pathology and cathepsin activity in a mouse model

This study investigates the effect of Cstb duplication on amyloid-β pathology and cathepsin activity in a mouse model of Alzheimer's disease, finding no significant impact on Aβ levels or cathepsin activity.

Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models

This study identifies non-APP chromosome 21 genes that influence amyloid-β biology in Down syndrome mouse models, independent of APP copy number.

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

The paper identifies distinct hippocampal and prefrontal cortex circuit dysfunctions in DS mouse models linked to specific regions of human chromosome 21.