BioinformaticsbioRxivPreprint
MicroGenomer: A Foundation Model for Transferable Microbial Genome Representations Enabling Multi-scale Genomic Understanding and Ecophysiological Trait Prediction
DOI 10.64898/2025.12.28.696777
Author
Haochen Wang
Beijing National Research Center for Information Science and TechnologyORCID 0000-0003-1191-6682Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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Recent·Most cited
- Synthetic BiologybioRxivPreprint
PccGEO: prior constraints conditioned genetic elements optimization
Hanwen Xu, Pengcheng Zhang, Haochen Wang…·Xiaowo Wang
PccGEO designs functional genetic elements using a knowledge-constrained deep learning model, achieving high success rates in promoter design for E. coli.
DOI 10.1101/2021.11.08.467823 - BioinformaticsBriefings in BioinformaticsPeer-reviewed
DISMIR: a deep learning-based cancer-detection method by integrating DNA sequence and methylation information of individual cell-free DNA reads
Jiaqi Li, Lei Wei, Xianglin Zhang…·Xiaowo Wang
DISMIR detects cancer using cfDNA methylation and sequence data with high accuracy at low sequencing depth.
67 citationstop 3% - BioinformaticsNucleic Acids ResearchPeer-reviewed
Synthetic Promoter Design in Escherichia coli based on Generative Adversarial Network
Ye Wang, Haochen Wang, Lei Wei…·Xiaowo Wang
This study uses a generative adversarial network to design new functional promoters in E. coli, achieving higher success rates and activity than natural promoters.
212 citationstop 2%