Mats O. Karlsson

This study extends the integrated glucose-insulin model to include disease progression in individuals with impaired glucose tolerance, showing slower deterioration with lifestyle intervention.

This study evaluates two NLME model approaches for drug effect assessment in unbalanced designs and dose-response studies, finding that IMA and sIMA control type I error and bias, while STD does not.

This paper evaluates IMA and STD methods for drug effect testing using simulated data, finding IMA more robust to model misspecification with controlled type I error and unbiased estimates.