Raghu Prasad Rao Metpally

The paper identifies rare GPR37L1 variants associated with anxiety and migraine using computational analysis and functional experiments in cells and mice.

This study identifies 53 genetic loci associated with hearing loss, including 15 novel ones, using genome-wide and exome-sequencing data from multiple cohorts.

This paper integrates monogenic, polygenic, and clinical risk factors to predict disease risk for carriers of rare variants, identifying elevated risk in 18.22% of UK Biobank participants for breast cancer, familial hypercholesterolemia, and colorectal cancer.

The paper uses rare variant analyses to identify disease associations for understudied GPCRs, finding that rare synonymous variants can contribute to disease associations similar to loss-of-function and missense variants.

The paper examines how common variants in the calcium-sensing receptor gene influence the relationship between serum calcium levels and coronary artery disease risk.