Michael C. Lawrence

This study expands and differentiates adult human pancreas-derived progenitor cells into functional islet-like organoids using clinical tissue and validates their endocrine capabilities.

The paper identifies and characterizes islet pancridia cells (IPCs) from the adult pancreas that can differentiate into islet organoids, revealing calcium-dependent and epigenetic mechanisms involved in this process.

This study develops a personalized digital twin model for liver recovery using gene expression data from LDLT donors to predict individual recovery trajectories.